RESUMO
INTRODUCCIÓN: En los últimos años, se ha generado evidencia que demuestra el potencial que tiene la radiómica para futuras aplicaciones en numerosas situaciones clínicas, incluyendo la oncología torácica. Se han identificado varias razones metodológicas que justifican la inmadurez de los estudios sobre la minería de la imagen (basada en radiómica y en inteligencia artificial). No obstante, faltan datos sobre la influencia de la composición del equipo investigador sobre la calidad de las investigaciones en radiómica. OBJETIVOS: Esta revisión tiene como objetivo evaluar el carácter interdisciplinar dentro de los estudios sobre radiómica en oncología torácica, para evaluar su influencia sobre la calidad de la investigación (puntuación QUADAS-2) en el campo de la minería de la imagen. MÉTODOS: Se consideraron para inclusión estudios de radiómica con objetivos relacionados con la práctica clínica en oncología torácica. A continuación, se entrevistó a los autores responsables de la correspondencia de cada estudio seleccionado. El campo de conocimiento o el nivel educativo fue utilizado para evaluar el carácter interdisciplinar de los equipos investigadores. Después, todos los estudios fueron evaluados aplicando la previamente establecida puntuación QUADAS-2, asignando una fase de investigación de 0 a IV. RESULTADOS: En conjunto se incluyeron 27 estudios. La calidad de los estudios, basada en la puntuación QUADAS-2, fue baja (puntuación ≤ 5) en 8, moderada (= 6) en 12 y alta (≥ 7) en 7 artículos. Un equipo interdisciplinar (al menos 3 diferentes categorías de expertos) participó en la mitad de los estudios sin ningún tipo de confirmación y en todos los estudios con confirmación independiente. Los clínicos no participaron en los estudios fase 0, mientras que contribuyeron a todos los artículos clasificados como fase I y a 4 de 5 artículos clasificados como fase II con confirmación independiente. CONCLUSIONES: La composición del equipo de investigación influencia la calidad de las investigaciones en radiómica. También el incremento en el carácter interdisciplinar de los equipos de investigación aparentemente refleja el desarrollo de la investigación desde una fase temprana a una fase de mayor madurez y de mayor orientación clínica de la investigación
BACKGROUND: Recently, evidence has accumulated that demonstrates the potential for future applications of radiomics in many clinical settings, including thoracic oncology. Methodological reasons for the immaturity of image mining (radiomics and artificial intelligence-based) studies have been identified. However, data on the influence of the composition of the research team on the quality of investigations in radiomics are lacking. AIM: This review aims to evaluate the interdisciplinarity within studies on radiomics in thoracic oncology in order to assess its influence on the quality of research (QUADAS-2 score) in the image mining field. METHODS: We considered for inclusion radiomics investigations with objectives relating to clinical practice in thoracic oncology. Subsequently, we interviewed the corresponding authors. The field of expertise and/or educational degree was then used to assess interdisciplinarity. Subsequently, all studies were evaluated applying the QUADAS-2 score and assigned to a research phase from 0 to IV. RESULTS: Overall, 27 studies were included. The study quality according to the QUADAS-2 score was low (score ≤5) in 8, moderate (=6) in 12, and high (≥7) in 7 papers. An interdisciplinary team (at least 3 different expertise categories) was involved in half of the papers without any type of validation and in all papers with independent validation. Clinicians were not involved in phase 0 studies while they contributed to all papers classified as phase I and to 4/5 papers classified as phase II with independent validation. CONCLUSIONS: The composition of the research team influences the quality of investigations in radiomics. Also, growth in interdisciplinarity appears to reflect research development from the early phase to a more mature, clinically oriented stage of investigation
Assuntos
Humanos , Pesquisa Translacional Biomédica/métodos , Comunicação Interdisciplinar , Neoplasias Torácicas/diagnóstico por imagem , Interpretação de Imagem Assistida por Computador/métodos , Radioterapia (Especialidade)/tendênciasRESUMO
BACKGROUND: Recently, evidence has accumulated that demonstrates the potential for future applications of radiomics in many clinical settings, including thoracic oncology. Methodological reasons for the immaturity of image mining (radiomics and artificial intelligence-based) studies have been identified. However, data on the influence of the composition of the research team on the quality of investigations in radiomics are lacking. AIM: This review aims to evaluate the interdisciplinarity within studies on radiomics in thoracic oncology in order to assess its influence on the quality of research (QUADAS-2 score) in the image mining field. METHODS: We considered for inclusion radiomics investigations with objectives relating to clinical practice in thoracic oncology. Subsequently, we interviewed the corresponding authors. The field of expertise and/or educational degree was then used to assess interdisciplinarity. Subsequently, all studies were evaluated applying the QUADAS-2 score and assigned to a research phase from 0 to IV. RESULTS: Overall, 27 studies were included. The study quality according to the QUADAS-2 score was low (score ≤5) in 8, moderate (=6) in 12, and high (≥7) in 7 papers. An interdisciplinary team (at least 3 different expertise categories) was involved in half of the papers without any type of validation and in all papers with independent validation. Clinicians were not involved in phase 0 studies while they contributed to all papers classified as phase I and to 4/5 papers classified as phase II with independent validation. CONCLUSIONS: The composition of the research team influences the quality of investigations in radiomics. Also, growth in interdisciplinarity appears to reflect research development from the early phase to a more mature, clinically oriented stage of investigation.
